Scaffold hopping based lead finding

Using our Nested Chemical Library for hit finding against a particular kinase target, if our hits are patented or are in a heavily patented field, we perform a scaffold hopping technique to identify novel lead structures. We use our pharmacophore modeling technique including the computational screening of our 15 million compound synthesizable virtual library and our medicinal chemistry expertise to come up with novel patentable scaffolds. Our Master keys can also be the starting points for novel patentable scaffolds.

Based on the NCL/Master Key/Scaffold hopping techniques, if our partner names a kinase target and we have set up the biochemical kinase assay, in a year we can deliver a novel patentable, submicromolar kinase inhibitory lead structure.