The concept of Nested Chemical Library

Our Nested Chemical Library (NCL) technology is a novel hit and lead finding method for rational drug design of kinase inhibitors. The NCL relies on a systematically built knowledge base integrating our experience accumulated during the past more than 20 years of kinase inhibitory chemistry. Our library is organized around more than 110 core structures and more than 500 scaffolds. We have generated small focused sublibraries around each core. The NCL includes most of the preclinically and clinically relevant, published kinase inhibitors and a large series of patented compounds what we have developed previously and a series of novel patentable compounds.

The concept of NCL and CVL is aimed to:

• include the best published clinically and preclinically relevant kinase inhibitors
• continuously increase chemical diversity: >110 core structure, >500 scaffolds
• have inhibitors against increasing number of kinases (more than 150)
• continuous improvement, updating and extending
  • small focused libraries around hits
  • several thousands proprietary structures

Using NCL for a large series of kinase targets and even for cellular targets of infectious diseases or cancer the hit-rates were always above 3-5%.

Based on our unique NCL library we can perform pharmacophore model generation, scaffold hopping for novel patentable hits and hit/lead optimization.