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Master Library

The underlying Master Library (ML) includes novel compounds and analogue structures around CVL and EVL, extended with additional ~12.000 compounds. New potential hit molecules are filtered by their ADMET (Adsorption, Distribution, Metabolism, Excretion, Toxicity) properties, druglikeness and patentability. Typically, novel and potential kinase targets can be validated chemically by using the CVL compounds and than if robust assay is available the Master library compounds are also tested in biochemical assay for activity against the kinase of interest. The selected and active inhibitors of a particular kinase are applied to therapeutically relevant cellular assays, in order to confirm the role of the kinase activity in this biological model. Based on the biochemical assay data pharmacophore models are generated to select novel patentable leads.