Nested Chemical Library™ (NCL)
Our NCL is a “hit finding library” including most of the best published kinase inhibitors and several proprietary structures. NCL contains more than 12,000 compounds, more than 110 core structures and more than 600 scaffolds with proven kinase inhibitory activity on various kinase targets. We have inhibitors against more than 160 kinases.
Allosteric kinase inhibitory and modulatory library
We have developed an allosteric kinase inhibitory and modulatory library based on published allosteric kinase inhibitors and allosteric modulatory compounds. Applying Vichem’s special ‘theoretical interactive surface’ pharmacophore modeling on pre-filtered ‘non-ATP-like’ kinase inhibitors, we were able to identify the main structural features needed for allosteric binding.
You select the target, we deliver the patentable lead compound
Based on our NCL, Masterkey and scaffold hopping techniques, our partner selects a kinase target, we set up the biochemical kinase assay, and in a year we deliver a novel patentable, submicromolar kinase inhibitory lead structure.
Target fishing
We offer a sophisticated chemical derivatization and affinity chromatography based proteomic technology for selectivity profiling and off- target identification of kinase inhibitors. Chemical proteomics can be instrumental in unraveling unknown cellular modes of action of the investigated compound.
